28 February 2009

Researchers find new piece in the Alzheimer’s puzzle

Yale researchers have filled in a missing gap on the molecular road map of Alzheimer's disease.
Yale University: 25 February 2009
In the Feb. 26 issue of the journal Nature, the Yale team reports that cellular prion proteins trigger the process by which amyloid-beta peptides block brain function in Alzheimer's patients.

"It has been a black box," said Stephen M. Strittmatter, senior author of the study and the Vincent Coates Professor of Neurology and director of Cellular Neuroscience, Neurodegeneration and Repair at the Yale School of Medicine. "We have known that amyloid-beta is bad for the brain, but we have not known exactly how amyloid-beta does bad things to neurons."

After an extensive gene expression analysis, the first step in amyloid-beta damage appears to involve cellular prion proteins. These proteins are normally harmless and exist within all cells, but on rare occasions they change shape and cause notorious prion diseases such as Creutzfeldt- Jacob disease, or its well-known variant, mad cow disease. … > full story

No comments:

Post a Comment

Alzheimer's Australia NSW

Alzheimer's Australia NSW
Alzheimer's Australia NSW

Latest headlines from Library News

Library News

Total Pageviews