16 March 2009

Contribution of vascular risk factors to the progression in Alzheimer disease

Diabetes and elevated levels of cholesterol linked to faster cognitive decline in Alzheimer’s patients
Columbia University: 9 March 2009
Heart disease and stroke linked to increased cognitive decline only in Alzheimer’s patients who carry the APOE-e4 gene – previously implicated in late-onset disease

A history of diabetes and elevated levels of cholesterol, especially LDL cholesterol, are associated with faster cognitive decline in patients with Alzheimer’s disease, according to a new study from Columbia University Medical Center researchers. These results add further evidence of the role of vascular risk factors in the onset and progression of Alzheimer’s disease.

“These findings indicate that controlling vascular conditions may be one way to delay the course of Alzheimer’s, which would be a major development in the treatment of this devastating disease as currently there are few treatments available to slow its progression,” said Yaakov Stern, Ph.D., a professor at the Taub Institute for the Research on Alzheimer’s Disease and the Aging Brain and director of the Cognitive Neuroscience Division of the Gertrude H. Sergievsky Center at Columbia University Medical Center, and senior author of the paper. … > full press release : review by MedPage Today

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