4 April 2009

Alzheimer’s disease linked to mitochondrial damage

Free radical generated by beta-amyloid leads to mitochondrial fragmentation
Burnham Institute for Medical Research: 3 April 2009
Investigators at the Burnham Institute for Medical Research (Burnham) have demonstrated that attacks on the mitochondrial protein Drp1 by the free radical nitric oxide—which causes a chemical reaction called S-nitrosylation—mediates neurodegeneration associated with Alzheimer’s disease. Prior to this study, the mechanism by which beta-amyloid protein caused synaptic damage to neurons in Alzheimer’s disease was unknown. These findings suggest that preventing S-nitrosylation of Drp1 may reduce or even prevent neurodegeneration in Alzheimer’s patients. … > full story : comment from AlzForum

No comments:

Post a Comment

Alzheimer's Australia NSW

Alzheimer's Australia NSW
Alzheimer's Australia NSW

Latest headlines from Library News

Library News

Total Pageviews