25 May 2009

Histone deacetylase (HDAC) inhibitor drug research promising

Trial drugs 'reverse' Alzheimer's
BBC News: 6 May 2009
US scientists say they have successfully reversed the effects of Alzheimer's with experimental drugs.

The drugs target and boost the function of a newly pinpointed gene involved in the brain's memory formation.

In mice, the treatment helped restore long-term memory and improve learning for new tasks, Nature reports. … > full story : review by NHS Knowledge Service

NHS Knowledge Service comments: “This study will be of interest to those researching new treatments and approaches to Alzheimer’s disease. The fact that reduced neuronal levels of HDAC2 but not HDAC1 increase synaptic plasticity, memory formation and changes in the neurons that are associated with memory raises the possibility that drugs specifically targeted at HDAC2 might be of value in the treatment of human diseases associated with memory loss. Further research will clarify how close we are to any potential use of these drugs in humans with Alzheimer’s.”

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